Archive for the ‘Pharm’ Category

Zithromax.

Tuesday, September 25th, 2007

Zithromax is an antibiotic related to erythromycin. It is prescribed for adults to treat certain mild to moderate skin infections; upper and lower respiratory tract infections, including pharyngitis (strep throat), tonsillitis, worsening of chronic obstructive pulmonary disease, and pneumonia; sexually transmitted infections of the cervix or urinary tract; and genital ulcer disease in men. In children, Zithromax is used to treat middle ear infection, pneumonia, tonsillitis, and strep throat.

There is a possibility of rare but very serious reactions to Zithromax, including angioedema (swelling of the face, lips, and neck that impedes speaking, swallowing, and breathing), anaphylaxis (a violent, even fatal allergic reaction), and serious skin diseases. If you develop these symptoms, stop taking Zithromax and call your doctor immediately.

Take Zithromax capsules at least 1 hour before or 2 hours after a meal. Zithromax tablets and oral suspension can be taken with or without food. Do not take any form with an antacid that contains aluminum or magnesium, such as Di-Gel, Gelusil, Maalox, and others. If you are using single-dose packets of Zithromax powder for oral suspension, mix the entire contents of each packet with 2 ounces of water, drink immediately, then add an additional 2 ounces of water, mix again, and drink to make sure you’ve taken the entire dose. When giving the pediatric suspension, shake the bottle thoroughly before each use and measure the dose with the supplied calibrated dropper. Use the pediatric suspension within 10 days and throw out any that remains. Be sure to take all the drug prescribed. If you stop taking Zithromax too soon, some germs may survive and the illness may return. –If you miss a dose… Take the forgotten dose as soon as you remember. If you don’t remember until the next day, skip the dose and go back to your regular schedule. Never try to “catch up” by doubling the dose. –Storage instructions… Zithromax should be stored at room temperature.

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Zithromax. More common side effects may include: Abdominal pain, diarrhea or loose stools, nausea or vomiting Less common side effects may include: Blood in the stools, chest pain, dizziness, drowsiness, fatigue, gas, headache, heart palpitations, indigestion, itching, jaundice (yellowing of the skin and the whites of the eyes), kidney infection, light sensitivity, rash, severe allergic reaction including swelling (as in hives), vaginal inflammation, vertigo, yeast infection Other uncommon side effects sometimes seen in children include: Agitation, constipation, cough, facial swelling, feeling of illness, fever, fungal infection, insomnia, loss of appetite, nervousness, overactivity, pinkeye, runny nose, shortness of breath, sore throat, stomach inflammation, sweating The single large dose of Zithromax that is prescribed to treat sexually transmitted infection of the cervix or urinary tract is more likely to cause stomach and bowel side effects than the smaller doses prescribed for a skin or respiratory tract infection.

 

Do not take Zithromax if you have ever had an allergic reaction to it or to similar antibiotics such as erythromycin (E.E.S., PCE, and others).

Like certain other antibiotics, Zithromax may cause a potentially life-threatening form of diarrhea called pseudomembranous colitis. Pseudomembranous colitis may clear up spontaneously when the drug is stopped; if it doesn’t, hospital treatment may be required. If you develop diarrhea, check with your doctor immediately. If you have a liver problem, your doctor should monitor you very carefully while you are taking Zithromax.

Kamagra.

Friday, September 14th, 2007

Two chemicals are produced by the male body whilst sexually aroused – Cyclic GMP which causes the muscles in the arterial wall of the penis to relax allowing blood to flow in and phosphodiesterase type 5 (PDE-5) which decreases erections. Kamagra contains an ingredient called Sildenafil. Sildenafil is a PDE-5 inhibitor. Whilst active Kamagra causes a vigorous build up of Cyclic GMP causing the penis to stay erect. It must be noted that sexual simulation is required in order for Kamagra to become effective. It is recommended that no more than one 100mg tablet is taken in any 24 hr period. 

Under normal circumstances, side effects are mild and can include upset stomach, headache and facial flushing. Other possible, less common side effects are sensitivity to light and a bluish / blurred vision. If experiencing chest pains, nausea or dizziness during sex, seek immediate medical advice. 

Kamagra must be used under a doctors supervision. It is strongly recommended that you seek medical advice (all instances) to establish if your heart is healthy enough for sexual activity. Most importantly Kamagra should never be taken if you take any medicines that contain nitrates. Nitrates are commonly contained in drugs for the treatment of Angina. Examples of these are Nitroglycerin, Isosorbide Mononitrate and Isosorbide Dinitrate. Nitrates can also be found in recreational drugs such as Amyl Nitrate (known as Poppers). If you are unsure what nitrates are or need to establish if any medicines you are taking contain nitrates consult your doctor. Taking Kamagra with any medication containing nitrates can cause blood pressure to drop to an unsafe level. Possible effects can be dizziness, heart attack or stroke. If you have ever suffered from any of the following conditions inform your doctor before taking Kamagra. 

Your doctor can then inform you if it is safe to take Kamagra tablets, and if so, the appropriate dose. All Kamagra tablets sold on this site are 100mg. Smaller doses can be achieved by splitting the pills. For example, if you are over the age of 65 or have had liver /kidney problems, the appropriate dose may be 25mg. Also if you are taking alpha blockers no more than 25 mg of Kamagra should be taken within 4 hours of your alpha blocker dose. Under no circumstances should Kamagra be taken more than once a day. Kamagra should not be taken by women or by children under the age of 18.

Ultram.

Thursday, September 13th, 2007

Ultram, commonly prescribed because of their effective analgesic, or pain relieving properties. Many studies have shown that properly managed medical use of pain killer compounds is safe and rarely causes addiction. Taken exactly as prescribed, opioids can be used to manage pain effectively.

Among the compounds that fall within this class — sometimes referred to as narcotics — are morphine, codeine, and related medications. Morphine is often used before or after surgery to alleviate severe pain. Codeine is used for milder pain. Opioids act by attaching to specific proteins called opioids receptors, which are found in the brain, spinal cord, and gastrointestinal tract. When these compounds attach to certain opioids receptors in the brain and spinal cord, they can effectively change the way a person experiences pain. In addition, opioids medications can affect regions of the brain that mediate what we perceive as pleasure, resulting in the initial euphoria that many opioids produce. They can also produce drowsiness, cause constipation, and, depending upon the amount taken, depress breathing. Taking a large single dose could cause severe respiratory depression or death.

Chronic use of Ultram can result in tolerance to the medications so that higher doses must be taken to obtain the same initial effects. Long-term use also can lead to physical addiction — the body adapts to the presence of the substance and withdrawal symptoms occur if use is reduced abruptly. Individuals taking prescribed Ultram should not only be given these medications under appropriate medical supervision, but also should be medically supervised when stopping use in order to reduce or avoid withdrawal symptoms. Symptoms of withdrawal can include restlessness, muscle and bone pain, insomnia, diarrhea, vomiting, cold flashes with goose bumps (“cold turkey”), and involuntary leg movements.

Individuals who become addicted to Ultram can be treated. Options for effectively treating Ultram addiction to prescription opioids are drawn from research on treating heroin addiction.

 Prolonged use of these drugs eventually changes the brain in fundamental and long-lasting ways, explaining why people cannot just quit on their own, and why treatment is essential. In effect, drugs of abuse take over the brain’s normal pleasure and motivational systems, moving drug use to the highest priority in the individual’s motivational hierarchy, thereby overriding all other motivations and drives. These brain changes, then, are responsible for the compulsion to seek and use drugs that we have come to define as addiction.

Levitra.

Tuesday, September 11th, 2007

Levitra (Vardenafil) is an oral therapy for the treatment of erectile dysfunction.


Levitra (Vardenafil) comes as a tablet to take it orally. It should be taken, as needed about 1 hour before sexual activity. Some form of sexual stimulation is needed for an erection to occur with Levitra. Levitra should not be taken more than once a day. Levitra can be taken with or without food.

Levitra (Vardenafil) is an oral drug that is used to treat impotence (the inability to attain or maintain a penile erection.). It is a phosphodiesterase inhibitor that is similar to sildenafil (Viagra).
Penile erection is caused by the engorgement of the penis with blood. This engorgement occurs when the blood vessels delivering blood to the penis increase in size and increase the delivery of blood to the penis. At the same time, the blood vessels carrying blood away from the penis decrease in size and decrease the removal of blood from the penis. Sexual stimulation that leads to the engorgement and erection causes the production and release of nitric oxide in the penis. Nitric oxide then activates the enzyme, guanylate cyclase to produce cyclic guanosine monophosphate (cGMP). The cGMP is primarily responsible for increasing and decreasing the size of the blood vessels carrying blood to and from the penis, respectively. Vardenafil prevents an enzyme called phosphodiesterase-5 from destroying cGMP so that cGMP persists longer. The longer cGMP persists, the more prolonged the engorgement of the penis.

 
Before taking Levitra (Vardenafil), tell your doctor if you currently have or have ever had a heart attack, stroke, irregular heartbeats, angina (chest pain), or congestive heart failure; high or low blood pressure; if you have a personal or family history of a rare heart condition known as prolongation of the QT interval (long QT syndrome); liver problems or kidney problems; have ever had blood problems, including sickle cell anemia, multiple myeloma, or leukemia; have a bleeding or blood clotting disorder; have a stomach ulcer; a family history of degenerative eye disease (e.g., retinitis pigmentosa); or if you have a physical deformity of the penis such as Peyronie’s disease. You may not be able to take Levitra, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above. Although women do not indicate Levitra for use, it is in the FDA pregnancy category B. This means that Levitra is not expected to be harmful to an unborn baby. Women should not take Levitra. It is not known whether Levitra passes into breast milk. If you are over 65 years of age, you may be more likely to experience side effects from Levitra. Your doctor may prescribe a lower dose of the medication.

Questions and Answers for Cialis (tadalafil)

Tuesday, March 27th, 2007

1.  What is Cialis used to treat?

         Cialis is approved for the treatment of men who experience difficulty having and maintaining an erection (impotence).

2.  How does Cialis work?

Cialis works by enhancing the effects of one of the chemicals the body normally releases into the penis during sexual arousal. This allows an increase of blood flow into the penis. An erection is the result of an increase in blood flow into certain internal areas of the penis.

3.  How is Cialis different from the currently approved products for erectile dysfunction (ED)?

Cialis is different from other currently approved products for ED in that it stays in the body longer. However, there were no studies that directly compared the clinical efficacy and safety of Cialis to other products.

4.  How do I take Cialis?

Cialis is taken orally before sexual activity, not more than once daily. Cialis may be taken with or without food. In some patients, the dose strength and maximum frequency of use may be adjusted. For more detailed information consult with your health care provider.

5.  Are there any side effects with Cialis?

As with any drug product, there may be side effects. The most commonly reported side effects in patients treated with Cialis during the testing of the product were:

  • headache
  • indigestion
  • back pain
  • muscle pain
  • flushing
  • stuffy nose

Patients who get back pain and muscle aches usually get them 12 to 24 hours after taking Cialis and these usually go away by themselves within 48 hours. A small number of patients taking Cialis also reported abnormal vision.

6.  What important information should you know about Cialis?:

· CIALIS can cause your blood pressure to drop suddenly to an unsafe level if it is taken with any nitrate medication or with any alpha-blocker medication (alpha blockers are medicines used to treat benign prostatic hyperplasia and high blood pressure) other than FLOMAX (tamsulosin) 0.4 mg daily. You could get dizzy, faint or have a heart attack or stroke.

· Tell your healthcare provider that you take Cialis. If you need emergency medical care for a heart problem, it will be important for your health care provider to know when you last took Cialis.

· After taking a single tablet, some of the active ingredient of Cialis remains in your body for more than 2 days. The active ingredient can remain longer if you have problems with your kidneys or liver, or you are taking certain other medications.

7.  What should I talk to my doctor about when considering if Cialis is right for me?

Because sexual activity can increase the work of the heart, your doctors should talk to you about your heart’s general condition and if Cialis is right for you. Patients who have a condition called “left ventricular outlet obstruction” from valvular problems or heart muscle enlargement may get side effects such as fainting or light-headedness. Because patients with recent heart attacks or stroke, heart pains (angina), heart failure, uncontrolled blood pressure or uncontrolled irregular heart beats, severe liver disease, and retinal eye problems were not studied with Cialis, Cialis is not recommended for these patients. There may be rare occurrences of priapism or painful, prolonged erections. This is a serious condition that requires immediate medical attention. Patients should seek prompt medical attention if their erection lasts longer than four hours.

8.  Who should not take Cialis?

Cialis should not be used by patients taking nitrates (such as nitroglycerin tablets or patches) or any alpha blocker other than FLOMAX 0.4mg daily because the combination of these with Cialis could significantly lower blood pressure and lead to fainting or even death in some men.

9.  Can Cialis be used with other treatments for impotence?

The safety and effectiveness of Cialis when used with other treatments for impotence has not been studied. Combined use could lead to additional lowering of blood pressure, possibly to unsafe levels. Therefore the use of such treatments in combination with Cialis is not recommended.

10. What if I am taking other drugs?

Always discuss with your health care practitioner ALL of the medications you are taking (prescription and over-the-counter) that way, you can receive the best advice for your own situation. Cialis is not recommended for people taking any form of nitroglycerin and most alpha-blockers, other than FLOMAX, because the combination may lower blood pressure to an unsafe level.

11.  How will Cialis be supplied?

Cialis will be available as oral tablets in 5mg, 10mg and 20mg strengths.

12. Will Cialis be prescription or OTC (over-the-counter)?

Cialis will be available by prescription only.

13.  When will Cialis be available to pharmacies?

FDA has no control over when products are available in pharmacies after FDA approval for marketing. The decision of availability is completely up to the company marketing the product. For further information contact your pharmacist or Eli Lilly and Company directly.

14.  How can I report a serious side effect with Cialis to FDA?

FDA encourages anyone aware of a serious side effect, including consumers or patients, to make a MedWatch report.

Call 1-800-FDA-1088

GPs slam delay on brittle bone drugs

Tuesday, March 6th, 2007

Thousands of women with the brittle bone disease osteoporosis have been denied the necessary drugs to ease their condition because the medical debate about the most cost-effective treatment has taken five years to complete.Sufferers in some areas have been faced with ‘treatment blight’ - the reluctance of doctors to prescribe drugs because no decision has been made by Nice, the independent body that decides which drugs can be used.

Fewer than 500,000 of the three million people with brittle bone disease have received drugs that reduce their chances of sustaining a fracture, according to evidence assembled by the National Osteoporosis Society. ‘The upshot must be that more patients will have suffered broken hips than were necessary because some of the patients that might have had their bone density improved haven’t been able to get hold of drugs,’ said a spokesman.

Nice is finally due to reveal its findings tomorrow, although it is expected to impose age conditions on treatment. Critics have warned that this is likely to force the NHS to spend even more than the existing £1.73bn a year on treating the affects of osteoporosis when a course of drugs that costs as little as 27p a day can reduce the risk of fracture by up to half.

The society, whose patron is the Duchess of Cornwall, calls osteoporosis ‘Britain’s silent epidemic’. One in two women over 50 and one in five men of the same age are affected. Treatment of broken hips and vertebrae costs the NHS about the same as dealing with heart disease, and a broken hip means an average of 26 days in hospital.

The society, whose members include senior medical experts on the condition, has evidence that doctors have been waiting to see what Nice’s final recommendations are before prescribing a course of drugs. It claims that this ‘treatment blight’ means that some GPs have not been implementing Nice’s existing guidance on osteoporosis.

For example, present rules say that most women over 65 who have already had a fracture should receive a drug treatment. But the society’s research shows that, one year after fracture, most patients have not been prescribed a drug to prevent another breakage.

‘The Nice advice has been a long time coming - it’s been looking into this for five years - and has left the medical community uncertain what to do,’ said a society official. ‘We’re concerned that doctors’ disinclination to prescribe osteoporosis drugs, pending Nice’s final decision, is one reason why only 480,000 of Britain’s three million sufferers currently receive any form of drug treatment.’

Dr Mayur Lakhani, president of the Royal College of General Practitioners, confirmed that some doctors were not prescribing drugs due both to financial constraints and clinical and scientific uncertainty about the most effective treatments. ‘There’s a policy vacuum and lack of clear policy on osteoporosis in the NHS generally, not just with Nice,’ he said. ‘We need clarity on this, because osteoporosis is an important and common condition that the NHS doesn’t tackle effectively. More needs to be done. There are some difficult decisions to be made here and I hope Nice can help resolve some of these issues.’

A spokeswoman for Age Concern said: ‘We strongly urge Nice to make the right decision and ensure older people get access to the drugs and treatment that they need.’ Nice declined to comment before its advice was published.

ZOCOR (simvastatin)

Monday, March 5th, 2007

USES OF ZOCOR

ZOCOR is a prescription drug that is indicated as an addition to diet for many patients with high cholesterol. For patients at high risk of coronary heart disease (CHD) because of existing heart disease, diabetes, vascular disease, or history of stroke, ZOCOR is indicated along with diet to reduce the risk of death by reducing coronary death; reduce the risk of heart attack and stroke; and reduce the need for revascularization procedures.

WHEN ZOCOR SHOULD NOT BE USED

ZOCOR should not be used by patients who are allergic to any of its ingredients. In addition to the active ingredient simvastatin, each tablet contains the following inactive ingredients: cellulose, lactose, magnesium stearate, iron oxides, talc, titanium dioxide, and starch. Butylated hydroxyanisole is added as a preservative.

Patients with liver problems: ZOCOR should not be used by patients with active liver disease or repeated blood test results indicating possible liver problems. (See WARNINGS.)

Women who are or may become pregnant: Pregnant women should not take ZOCOR because it may harm the fetus. Women of childbearing age should not take ZOCOR unless it is highly unlikely that they will become pregnant. If a woman does become pregnant while on ZOCOR, she should stop taking the drug and talk to her doctor at once.

Women who are breast-feeding should not take ZOCOR.

SIDE EFFECTS

Most patients tolerate treatment with ZOCOR well; however, like all prescription drugs, ZOCOR can cause side effects, and some of them can be serious. Side effects that do occur are usually mild and short-lived. Only your doctor can weigh the risks versus the benefits of any prescription drug. In clinical studies with ZOCOR, less than 1.5% of patients dropped out of the studies because of side effects. In 2 large, 5-year studies, patients taking ZOCOR experienced similar side effects to those patients taking placebo (sugar pills). Some of the side effects that have been reported with ZOCOR or related drugs are listed below. This list is not complete. Be sure to ask your doctor about side effects before taking ZOCOR and to discuss any side effects that occur.

Digestive System: Constipation, diarrhea, upset stomach, gas, heartburn, stomach pain/cramps, anorexia, loss of appetite, nausea, inflammation of the pancreas, hepatitis, jaundice, fatty changes in the liver, and, rarely, severe liver damage and failure, cirrhosis, and liver cancer.

Muscle, Skeletal: Muscle cramps, aches, pain, and weakness; joint pain; muscle breakdown.

Nervous System: Dizziness, headache, insomnia, tingling, memory loss, damage to nerves causing weakness and/or loss of sensation and/or abnormal sensations, anxiety, depression, tremor, loss of balance, psychic disturbances.

Skin: Rash, itching, hair loss, dryness, nodules, discoloration.

Eye/Senses: Blurred vision, altered taste sensation, progression of cataracts, eye muscle weakness.

Hypersensitivity (Allergic) Reactions: On rare occasions, a wide variety of symptoms have been reported to occur either alone or together in groups (referred to as a syndrome) that appeared to be based on allergic-type reactions, which may rarely be fatal. These have included 1 or more of the following: a severe generalized reaction that may include shortness of breath, wheezing, digestive symptoms, and low blood pressure and even shock; an allergic reaction with swelling of the face, lips, tongue, and/or throat with difficulty swallowing or breathing; symptoms mimicking lupus (a disorder in which a person’s immune system may attack parts of his or her own body); severe muscle and blood vessel inflammation, sometimes including rash; bruises; various disorders of blood cells (that could result in anemia, infection, or blood clotting problems) or abnormal blood tests; inflamed or painful joints; hives; fatigue and weakness; sensitivity to sunlight; fever, chills; flushing; difficulty breathing; and severe skin disorders that vary from rash to a serious burn-like shedding of skin all over the body, including mucous membranes such as the lining of the mouth.

Other: Loss of sexual desire, breast enlargement, impotence.

Laboratory Tests: Liver function test abnormalities including elevated alkaline phosphatase and bilirubin; thyroid function abnormalities.

Cialis Side Effects

Sunday, March 4th, 2007

Cialis was administered to over 4000 subjects (aged 19 to 86 years) during clinical trials worldwide. Over 230 patients were treated for longer than one year and over 720 patients were treated for over 6 months. In controlled phase 2/3 clinical trials, the discontinuation rate due to Cialis side effects (1.7%) was not significantly different from placebo-treated patients (1.1%). In these studies, the side effects reported with Cialis were generally mild or moderate, transient, and decreased with continued dosing.

Like all prescription medications, Cialis may produce some side effects. These side effects are generally mild to moderate in nature, and usually go away within a few hours of use.

The following Cialis side effects have been reported:

  • Headache
  • Back pain: In clinical trials, Back pain or myalgia was reported to occur 12 to 24 hours after dosing and typically resolved within 48 hours. This side effect was characterized by discomfort in the diffuse bilateral lumbar, gluteal, thigh, or thoracolumbar muscular discomfort. In general, the pain was reported as mild or moderate in severity and resolved without medical treatment, but severe back pain was reported infrequently (<5% of all reports).
  • Colour Vision: Changes in colour vision is rare. Across all studies, (<0.1%) of patients experienced it.
  • Effects on the Digestive System: Effects include diarrhea, dry mouth, dysphagia, esophagitis , abnormal liver, loose stools, nausea, upper abdominal pain, vomiting and gastroesophageal reflux.
  • Nervous: Dizziness, hypesthesia, insomnia, paresthesia, somnolence and vertigo.
  • Cardiovascular: Angina pectoris, chest pain, hypotension, hypertension, myocardial infarction, and palpitations.
  • Musculoskeletal: Arthralgia, neck pain.
  • Respiratory: Dyspnea, epistaxis and pharyngitis.
  • Nasal congestion
  • Flushing

There may be additional unreported Cialis side effects.

Effect of other drugs on Cialis

Cytochrome P450 Inhibitors

CIALIS is predominantly metabolized by CYP3A4. Studies have shown that drugs that inhibit CYP3A4 can increase Tadalafil exposure

  • Ketoconazole - Ketoconazole , a selective inhibitor of CYP3A4, increases Tadalafil 20-mg single-dose exposure (AUC) by 312% and C max by 22%, relative to the values for Tadalafil 20 mg alone. Ketoconazole (200 mg) increases Tadalafil 10-mg single-dose exposure (AUC) by 107% and C max by 15%, relative to the values for Tadalafil 10 mg alone.
  • HIV Protease inhibitor - Ritonavir (200 mg twice daily), increases Tadalafil 20-mg single-dose exposure (AUC) by 124% with no change in C max , relative to the values for Tadalafil 20 mg alone. Other HIV protease inhibitors can also increase Tadalafil exposure.
  • Other cytochrome P450 inhibitors - Although specific interactions have not been studied, other CYP3A4 inhibitors, such as erythromycin, itraconazole, and grapefruit juice, would likely increase Tadalafil exposure.

Cytochrome P450 Inducers
Studies have shown that drugs that induce CYP3A4 can decrease tadalafil exposure.

  • Rifampin - Rifampin (600 mg daily), reduces Tadalafil 10-mg single-dose exposure (AUC) by 88% and C max by 46%, relative to the values for Tadalafil 10 mg alone.
  • Other CYP3A4 inducers, such as carbamazepine, phenytoin, and phenobarbitol, can decrease Tadalafil exposure.

Gastrointestinal Drugs

  • H 2 antagonists - An increase in gastric pH resulting from dosage of nizatidine has no significant effect on Tadalafil.
  • Antacids - Simultaneous administration of an antacid (magnesium hydroxide/aluminum hydroxide) and Tadalafil reduces the apparent rate of absorption of Tadalafil without altering exposure (AUC) to Tadalafil.

Effects of CIALIS on Other Drugs

  • Drugs Metabolized by Cytochrome P450

CIALIS does not inhibit or induce drugs metabolized by Cytochrome P450 (CYP) isoforms.

  • Alcohol: Both alcohol and CIALIS, a PDE5 inhibitor, act as mild vasodilators. When mild vasodilators are taken in combination, blood-pressure-lowering effects of each individual compound may be increased. Substantial consumption of alcohol (e.g., 5 units or greater) in combination with CIALIS can lead to increase in heart rate, decrease in standing blood pressure, dizziness, and headache.
  • Anti-Hypertensives: Clinical studies were conducted to assess the effect of Tadalafil on the blood-pressure-lowering effects of selected anti-hypertensive medications.
  • Alpha Blockers: When Tadalafil was administered to patients taking Doxazosin , there was significant augmentation of the blood-pressure-lowering effect of doxazosin.