Cialis online.

Cialis is used to treat erectile dysfunction (impotence; inability to get or keep an erection) in men. Cialis is in a class of medications called phosphodiesterase (PDE) inhibitors. It works by increasing blood flow to the penis during sexual stimulation. This increased blood flow can cause an erection. Cialis does not cure erectile dysfunction or increase sexual desire. Cialis does not prevent pregnancy or the spread of sexually transmitted diseases such as human immunodeficiency virus (HIV). 

Cialis comes as a tablet to take by mouth. It is usually taken with or without food before sexual activity. Your doctor will help you decide the best time for you to take Cialis before sexual activity. Cialis should not be taken more often than once every 24 hours. If you have certain health conditions or are taking certain medications, your doctor may tell you to take Cialis less often. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Cialis exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.  

Your doctor will probably start you on an average dose of Cialis and increase or decrease your dose depending on your response to the medication. Tell your doctor if Cialis is not working well or if you are experiencing side effects.  

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information. 

Tell your doctor and pharmacist if you are allergic to Cialis or any other medications. do not take Cialis if you are taking alpha blockers such as alfuzosin (Uroxatral), doxazosin (Cardura), prazosin (Minipress), and terazosin (Hytrin). However, you may take Cialis if you are taking an alpha blocker called tamsulosin (Flomax) at a dose of 0.4 mg daily. Also do not take Cialis if you are taking or have recently taken nitrates such as isosorbide dinitrate (Isordril, Sorbitrate), isosorbide mononitrate (Imdur, ISMO), and nitroglycerin (Nitro-BID, Nitro-Dur, Nitroquick, Nitrostat, others). Nitrates come as tablets, sublingual (under the tongue) tablets, sprays, patches, pastes, and ointments. Ask your doctor if you are not sure if any of your medications contain nitrates.

Tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention any of the following: antifungals such as fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral); carbamazepine (Tegretol); cimetidine (Tagamet); clarithromycin (Biaxin); cyclosporine (Neoral, Sandimmune); danazol (Danocrine); delavirdine (Rescriptor); dexamethasone (Decadron); diltiazem (Cardizem, Dilacor, Tiazac); erythromycin (E.E.S., E-Mycin, Erythrocin); ethosuximide (Zarontin); fluoxetine (Prozac, Sarafem); fluvoxamine (Luvox); HIV protease inhibitors such as indinavir (Crixivan), nelfinavir (Viracept), and ritonavir (Norvir); isoniazid (INH, Nydrazid); medications for high blood pressure; metronidazole (Flagyl); nefazodone (Serzone);other medications or treatments for erectile dysfunction; phenobarbital (Luminal, Solfoton); phenytoin (Dilantin); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane); troleandomycin (TAO), verapamil (Calan, Covera, Isoptin, Verelan), and zafirlukast (Accolate). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

Tell your doctor if you have or have ever had an erection that lasted more than 4 hours; a condition that affects the shape of the penis such as angulation, cavernosal fibrosis, or Peyronie’s disease; high or low blood pressure; irregular heartbeat; a heart attack; angina (chest pain); a stroke; ulcers in the stomach or intestine; a bleeding disorder; blood cell problems such as sickle cell anemia (a disease of the red blood cells), multiple myeloma (cancer of the plasma cells), or leukemia (cancer of the white blood cells); and liver, kidney, or heart disease. Also tell your doctor if you or any of your family members have or have ever had an eye disease such as retinitis pigmentosa. Tell your doctor if you have ever been advised by a health care professional to avoid sexual activity for medical reasons or if you have ever experienced chest pain during sexual activity. you should know that tadalafil is only for use in males. Women should not take tadalafil, especially if they are or could become pregnant or are breast-feeding. If a pregnant woman takes tadalafil, she should call her doctor. if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking tadalafil. ask your doctor about the safe use of alcoholic beverages while you are taking tadalafil. Alcohol can make the side effects from tadalafil worse. Your doctor will tell you how much alcohol you may drink while you are taking this medication.

You should know that sexual activity may be a strain on your heart, especially if you have heart disease. If you have chest pain during sexual activity, call your doctor immediately and avoid sexual activity until your doctor tells you otherwise.

Tell all your health care providers that you are taking tadalafil. If you ever need emergency medical treatment for a heart problem, the health care providers who treat you will need to know when you last took tadalafil.

1.  What is Cialis used to treat?

         Cialis is approved for the treatment of men who experience difficulty having and maintaining an erection (impotence).

2.  How does Cialis work?

Cialis works by enhancing the effects of one of the chemicals the body normally releases into the penis during sexual arousal. This allows an increase of blood flow into the penis. An erection is the result of an increase in blood flow into certain internal areas of the penis.

3.  How is Cialis different from the currently approved products for erectile dysfunction (ED)?

Cialis is different from other currently approved products for ED in that it stays in the body longer. However, there were no studies that directly compared the clinical efficacy and safety of Cialis to other products.

4.  How do I take Cialis?

Cialis is taken orally before sexual activity, not more than once daily. Cialis may be taken with or without food. In some patients, the dose strength and maximum frequency of use may be adjusted. For more detailed information consult with your health care provider.

5.  Are there any side effects with Cialis?

As with any drug product, there may be side effects. The most commonly reported side effects in patients treated with Cialis during the testing of the product were:

• headache
• indigestion
• back pain
• muscle pain
• flushing
• stuffy nose

Patients who get back pain and muscle aches usually get them 12 to 24 hours after taking Cialis and these usually go away by themselves within 48 hours. A small number of patients taking Cialis also reported abnormal vision.

6.  What important information should you know about Cialis?:

· CIALIS can cause your blood pressure to drop suddenly to an unsafe level if it is taken with any nitrate medication or with any alpha-blocker medication (alpha blockers are medicines used to treat benign prostatic hyperplasia and high blood pressure) other than FLOMAX (tamsulosin) 0.4 mg daily. You could get dizzy, faint or have a heart attack or stroke.

· Tell your healthcare provider that you take Cialis. If you need emergency medical care for a heart problem, it will be important for your health care provider to know when you last took Cialis.

· After taking a single tablet, some of the active ingredient of Cialis remains in your body for more than 2 days. The active ingredient can remain longer if you have problems with your kidneys or liver, or you are taking certain other medications.

7.  What should I talk to my doctor about when considering if Cialis is right for me?

Because sexual activity can increase the work of the heart, your doctors should talk to you about your heart’s general condition and if Cialis is right for you. Patients who have a condition called “left ventricular outlet obstruction” from valvular problems or heart muscle enlargement may get side effects such as fainting or light-headedness. Because patients with recent heart attacks or stroke, heart pains (angina), heart failure, uncontrolled blood pressure or uncontrolled irregular heart beats, severe liver disease, and retinal eye problems were not studied with Cialis, Cialis is not recommended for these patients. There may be rare occurrences of priapism or painful, prolonged erections. This is a serious condition that requires immediate medical attention. Patients should seek prompt medical attention if their erection lasts longer than four hours.

8.  Who should not take Cialis?

Cialis should not be used by patients taking nitrates (such as nitroglycerin tablets or patches) or any alpha blocker other than FLOMAX 0.4mg daily because the combination of these with Cialis could significantly lower blood pressure and lead to fainting or even death in some men.

9.  Can Cialis be used with other treatments for impotence?

The safety and effectiveness of Cialis when used with other treatments for impotence has not been studied. Combined use could lead to additional lowering of blood pressure, possibly to unsafe levels. Therefore the use of such treatments in combination with Cialis is not recommended.

10. What if I am taking other drugs?

Always discuss with your health care practitioner ALL of the medications you are taking (prescription and over-the-counter) that way, you can receive the best advice for your own situation. Cialis is not recommended for people taking any form of nitroglycerin and most alpha-blockers, other than FLOMAX, because the combination may lower blood pressure to an unsafe level.

11.  How will Cialis be supplied?

Cialis will be available as oral tablets in 5mg, 10mg and 20mg strengths.

12. Will Cialis be prescription or OTC (over-the-counter)?

Cialis will be available by prescription only.

13.  When will Cialis be available to pharmacies?

FDA has no control over when products are available in pharmacies after FDA approval for marketing. The decision of availability is completely up to the company marketing the product. For further information contact your pharmacist or Eli Lilly and Company directly.

14.  How can I report a serious side effect with Cialis to FDA?

FDA encourages anyone aware of a serious side effect, including consumers or patients, to make a MedWatch report.

Call 1-800-FDA-1088

Cialis was administered to over 4000 subjects (aged 19 to 86 years) during clinical trials worldwide. Over 230 patients were treated for longer than one year and over 720 patients were treated for over 6 months. In controlled phase 2/3 clinical trials, the discontinuation rate due to Cialis side effects (1.7%) was not significantly different from placebo-treated patients (1.1%). In these studies, the side effects reported with Cialis were generally mild or moderate, transient, and decreased with continued dosing.

Like all prescription medications, Cialis may produce some side effects. These side effects are generally mild to moderate in nature, and usually go away within a few hours of use.

The following Cialis side effects have been reported:

• Headache
• Back pain: In clinical trials, Back pain or myalgia was reported to occur 12 to 24 hours after dosing and typically resolved within 48 hours. This side effect was characterized by discomfort in the diffuse bilateral lumbar, gluteal, thigh, or thoracolumbar muscular discomfort. In general, the pain was reported as mild or moderate in severity and resolved without medical treatment, but severe back pain was reported infrequently (<5% of all reports).
• Colour Vision: Changes in colour vision is rare. Across all studies, (<0.1%) of patients experienced it.
• Effects on the Digestive System: Effects include diarrhea, dry mouth, dysphagia, esophagitis , abnormal liver, loose stools, nausea, upper abdominal pain, vomiting and gastroesophageal reflux.
• Nervous: Dizziness, hypesthesia, insomnia, paresthesia, somnolence and vertigo.
• Cardiovascular: Angina pectoris, chest pain, hypotension, hypertension, myocardial infarction, and palpitations.
• Musculoskeletal: Arthralgia, neck pain.
• Respiratory: Dyspnea, epistaxis and pharyngitis.
• Nasal congestion
• Flushing

There may be additional unreported Cialis side effects.

Effect of other drugs on Cialis

Cytochrome P450 Inhibitors

CIALIS is predominantly metabolized by CYP3A4. Studies have shown that drugs that inhibit CYP3A4 can increase Tadalafil exposure

• Ketoconazole - Ketoconazole , a selective inhibitor of CYP3A4, increases Tadalafil 20-mg single-dose exposure (AUC) by 312% and C max by 22%, relative to the values for Tadalafil 20 mg alone. Ketoconazole (200 mg) increases Tadalafil 10-mg single-dose exposure (AUC) by 107% and C max by 15%, relative to the values for Tadalafil 10 mg alone.
• HIV Protease inhibitor - Ritonavir (200 mg twice daily), increases Tadalafil 20-mg single-dose exposure (AUC) by 124% with no change in C max , relative to the values for Tadalafil 20 mg alone. Other HIV protease inhibitors can also increase Tadalafil exposure.
• Other cytochrome P450 inhibitors - Although specific interactions have not been studied, other CYP3A4 inhibitors, such as erythromycin, itraconazole, and grapefruit juice, would likely increase Tadalafil exposure.

Cytochrome P450 Inducers
Studies have shown that drugs that induce CYP3A4 can decrease tadalafil exposure.

• Rifampin - Rifampin (600 mg daily), reduces Tadalafil 10-mg single-dose exposure (AUC) by 88% and C max by 46%, relative to the values for Tadalafil 10 mg alone.
• Other CYP3A4 inducers, such as carbamazepine, phenytoin, and phenobarbitol, can decrease Tadalafil exposure.

Gastrointestinal Drugs

• H 2 antagonists - An increase in gastric pH resulting from dosage of nizatidine has no significant effect on Tadalafil.
• Antacids - Simultaneous administration of an antacid (magnesium hydroxide/aluminum hydroxide) and Tadalafil reduces the apparent rate of absorption of Tadalafil without altering exposure (AUC) to Tadalafil.

Effects of CIALIS on Other Drugs

• Drugs Metabolized by Cytochrome P450

CIALIS does not inhibit or induce drugs metabolized by Cytochrome P450 (CYP) isoforms.

• Alcohol: Both alcohol and CIALIS, a PDE5 inhibitor, act as mild vasodilators. When mild vasodilators are taken in combination, blood-pressure-lowering effects of each individual compound may be increased. Substantial consumption of alcohol (e.g., 5 units or greater) in combination with CIALIS can lead to increase in heart rate, decrease in standing blood pressure, dizziness, and headache.
• Anti-Hypertensives: Clinical studies were conducted to assess the effect of Tadalafil on the blood-pressure-lowering effects of selected anti-hypertensive medications.
• Alpha Blockers: When Tadalafil was administered to patients taking Doxazosin , there was significant augmentation of the blood-pressure-lowering effect of doxazosin.